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- W2351381665 abstract "Purpose To investigate the relationship of the quantity of β-catenin in nuclei and cytoplasm with the cellular proliferation and infiltration on gastric carcinoma. Methods The quantity of β-catenin in nuclei and cytoplasm were analysed by ELISA;The expressions of cyclin D1, c-myc and Ki-67 were examined by immunohistochemistry (IHC). Results In 27 cases of gastric carcinoma, the ratio of β-catenin content between nuclei and cytoplasm was positively related to depth of infiltration ( r_s=0.392 25, P=0.043 0), the content of β-catenin in nuclei was positively related to the expression of c-myc(r_s=0.509 04, P=0.006 7), and also to the expression of cyclin D1 (r_s=0.399 92, P=0.038 7). The content of β-catenin in cytoplasm was also positively related to the expression of cyclin D1. However, the content of β-catenin in nuclei and the positive expression of cyclin D1 and c-myc had no relation with Ki-67. Conclusions The ratio of the content of β-catenin in nuclei to that of cytoplasm is closely correlated with tumoral infiltration, but not directly related to the Lauren classification of gastric carcinoma. The accumulation of β-catenin in nuclei might stimulate the expression of cyclin D1 and c-myc, and hence facilitate the proliferation of the tumor cells." @default.
- W2351381665 created "2016-06-24" @default.
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- W2351381665 date "2006-01-01" @default.
- W2351381665 modified "2023-09-23" @default.
- W2351381665 title "Role of β-catenin in proliferation and infiltration of gastric carcinoma" @default.
- W2351381665 hasPublicationYear "2006" @default.
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