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- W2351383994 abstract "AIM:To explore the regulatory effect of dendritic cells(DC) transfected with TGF-β1 gene on the secretion of IFN-γ and NO of T lymphocytic cells in the Lewis rats with experimental autoimmune myasthenia gravis(EAMG).METHODS: Twenty-five healthy female Lewis rats were divided randomly into 5 groups: normal group,EAMG group,DC treatment group,pcDNA3-TGFβ1-DC treatment group and normal saline group.All the rats except those in normal group were immunized with acetylcholine receptor(AChR) protein extracted from electric organ of Narcine timilei and completed Freund's adjuvant(CFA).2×106 pcDNA3-TGFβ1-DCs/rat were injected subcutaneously into the backs of the rats immunized 5 d earlier with AChR+CFA.The rats in DC treatment group and normal saline group were injected with untreated DCs and normal saline respectively.Seven weeks after the first immunization,T lymphocytic cells in every rat were separated from the spleen.After a 48-h culture,the content of IFN-γ in the supernatant was detected by ELISA and the level of NO on the T lymphocytic cells was examined using chemistry method.RESULTS:Low content of IFN-γ in the supernatant was found in the normal rats and the content increased markedly in EAMG rats(P0.01).No significant difference was observed in the contents of IFN-γ between EAMG group and pcDNA3-TGF-β1-DC group.The level of NO was low in normal rats but increased significantly in EAMG rats(P0.001).The level in pcDNA3-TGF-β1-DC group was higher than that in EAMG group(P0.05),but with no statistically difference between EAMG group,DC treatment group and normal saline group.CONCLUSION:The regulation of the excretion of IFN-γ and NO on T lymphocytic cells may play a critical role in the treatment with DCs transfected with pcDNA3-TGFβ1 in EAMG rats." @default.
- W2351383994 created "2016-06-24" @default.
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- W2351383994 date "2009-01-01" @default.
- W2351383994 modified "2023-09-26" @default.
- W2351383994 title "Regulatory effect of dendritic cells transfected with TGF-β1 gene on secretion of IFN-γ and NO of T lymphocytic cells in rats with experimental autoimmune myasthenia gravis" @default.
- W2351383994 hasPublicationYear "2009" @default.
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