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- W2351420853 abstract "Objective To investigate the correlation between C-reactive protein(CRP),endothelin-1(ET-1) levels and pulmonary hypertension(PHT) in patients with chronic obstructive pulmonary disease(COPD).Methods Serum CRP and ET-1 levels of peripheral blood from 110 patients with COPD were detected;meanwhile pulmonary arterial systolic pressure was measured by echocardiography.Results Among 110 cases,PHT was present in 60 cases,and was absent in other 50 cases.Serum CRP and ET-1 levels were significantly higher in patients with PHT than those in patients without PHT(P0.05);there were significant positive correlations between the serum ET-1 level and CRP level in patients with COPD(r=0.705,P0.01);there were significant positive correlations between pulmonary arterial systolic pressure and the levels of serum ET-1 and CRP in patients with COPD(r=0.462,0.532,P0.01).Conclusion CRP and ET-1 level correlate to PHT in patients with COPD.CRP and ET-1 may play a role in the pathogenesis of PHT in patients with COPD.Systemic inflammation may play a role in the pathogenesis of PHT secondary to COPD patients." @default.
- W2351420853 created "2016-06-24" @default.
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- W2351420853 date "2011-01-01" @default.
- W2351420853 modified "2023-09-28" @default.
- W2351420853 title "Relationship between C-reactive protein,endothelin-1 levels and pulmonary hypertension in patients with chronic obstructive pulmonary disease" @default.
- W2351420853 hasPublicationYear "2011" @default.
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