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- W2351421652 abstract "[Objective] The aim of the research was to study the pharmacokinetics of amikacin sulfate in Anguilla japonica and its residue in tissues.[Method]The tissues were extracted with perchloric acid and purified by using solid-phase extraction.After pre-column derivatization with 2,4,6-trinitro-benzenesulfonic acid(TNBS),pyridine,4-dimethylaminopyridine and triflouroacetic aid,the pharmacokinetics and residue of amikacin sulfate were determined by high performance liquid chromatography with ultraviolet detection method.[Result]The obtained medicine by derivative method showed a good linear relationship in the range of 0.05 ~ 50 μg / ml(R = 0.999 5) and the lowest detection limit was0.05 μg / ml.The average recovery rate in blood and muscle was 75.9% and 76.9%.After 50 mg / kg amikacin sulfate was administrated by single-dose intramuscular injection at(26 ± 1) ℃,the drug concentration and time curve was accordant with a two-compartment open model.The peak time was 0.597 h and distribution half-life was 3.52 h,which showed the absorption and distribution of amikacin sulfate in Anguilla japonica was rapid.The peak concentration was 22.229 μg / ml and elimination half-time was 46.945 h,it was deduced that the residual time of drug was longer.After 50 mg / kg amikacin sulfate was injected in muscle of Anguilla japonica at(26 ± 1) ℃,amikacin sulfate wasn't detected in muscle tissues after 5 d,and amikacin sulfate wasn't detected in blood after 19 days.[Conclusion] The withdrawal time of amikacin sulfate in muscle of Anguilla japonica was 475- 513 d after intramuscular injection." @default.
- W2351421652 created "2016-06-24" @default.
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- W2351421652 date "2013-01-01" @default.
- W2351421652 modified "2023-09-25" @default.
- W2351421652 title "Studies on the Pharmacokinetics and Residue of Amikacin Sulfate in Anguilla japonica" @default.
- W2351421652 hasPublicationYear "2013" @default.
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