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- W2351433567 abstract "Objective:To investigate the expression and clinical significance of metastasis associated gene 1(MTA1) tumor metastasis suppressor gene KISS-1 in human gastric carcinoma. Methods:Immunnohistochemical technique was used to detect the MTAl and KISS-1 protein expression in 20 normal human gastric mucosa and 82 human gastric carcinoma samples.Results:The positive rate of MTA1 and KISS-1 protein was respectively 52.44% and 40.24% in gastric carcinoma and 5.00% and 90.00%in the normal gastric mucosa. Over-expression of MTA1 was significantly involved in the depth of invasion,grade,clinical stage,distant metastasis and lymph node metastasis(P0.01),and the similar results were found with the low expressed KISS-1 except the grade(P0.05).Yet,MTA1 expression was negatively related to KISS-1 in human gastric carcinoma (P0.01). Conclusion:Over-expression of MTA1 and low KISS-1 expression were significantly involved in infiltration and metastasis of the human gastric carcinoma,and the findings suggest that MTA1 and KISS-1 may be useful markers for evaluation of tumor malignancy,predication of recurrence,metastasis and prognosis in gastric carcinoma patients,which is likely to be new target of gene therapy of gastric carcinoma." @default.
- W2351433567 created "2016-06-24" @default.
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- W2351433567 date "2010-01-01" @default.
- W2351433567 modified "2023-09-28" @default.
- W2351433567 title "Expression and clinical significance of MTA1 and KISS-1 in human gastric carcinoma" @default.
- W2351433567 hasPublicationYear "2010" @default.
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