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- W2351444363 abstract "In this study we have investigated the influence of nicotine on nitric oxide synthase (NOS) activity in the striatum of 1 methyl 4 phenyl 1,2,3,6 tetrahydropyridine (MPTP) induced Parkinson disease (PD) model of C57BL mice. The effects of MPTP and nicotine on NOS activity,on levels of dopamine (DA), 3,4 dihydroxyphenlacetic acid (DOPAC), hemovanillic acid (HVA) ,and on tyrosine hydroxylase (TH)postive nerve fibres and neuron nitric oxide synthase(nNOS) postive neurons were measured by using colorimetic analysis, HPLC with electrochemical detection, and immunohistochemical analysis. NOS activity in the striatum of MPTP treated C57BL mice was significantly higher than the control mice. Nicotine might inhibit the increased NOS activity (15.63 IU±1.5 IU vs 13.09 IU±0.89 IU;per mg of protein, P 0.01) and nNOS postive neurons (68.61±3.84 vs 39.26±2.64, P 0.01). Nicotine significantly attenuated MPTP induced depletions of striatal DA (0.73 μg±0.28 μg vs 1.40 μg±0.19 μg,per g of the striatum, P 0.01),DOPAC(0.41 μg±0.13 μg vs 0.90 μg±0.09 μg,per g of the striatum, P 0.01),HVA (0.31 μg±0.07 μg vs 0.47 μg±0.19 μg,per g of the striatum, P 0.01) and the destruction of TH postive nerve fibres. We concluded nicotine may protect C57BL mice against MPTP induced dopaminergic neurotoxicity by inhibiting nNOS activity. [" @default.
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- W2351444363 date "2002-01-01" @default.
- W2351444363 modified "2023-09-27" @default.
- W2351444363 title "Influence of nicotine on the striatum NOS activity in MPTP-PD mice" @default.
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