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• W2351464009 abstract "Objective:This study was designed to prove simultaneously blocking both EGFR and COX-2-mediated pathways may be an efficient means of inhibiting cancer cell growth in NPC.Method:A combination of tarceva(EGFR-selectivetyrosine kinase inhibitors)with celecoxib(Cox-2 inhibitor)was studied on its effects on cell growth,cell cycle progression,apoptosis and protein expression in CNE-2 cell lines by cell growth assay,flow cytometric analysis assay and Western blotting.Result:①The inhibition rate of cell growth was higher in the group treated with a combination of two agents than that the sum of rates of the two groups treated with only one agent(P0.05).②The combination of tarceva with celecoxib significantly induced G1 arrest(P0.05),but did not increase apoptosis rate(P0.05).③The group of combination showed less expressions of p-EGFR and COX-2 than any other group.Conclusion:Simultaneously blocking EGFR and COX-2 mediated pathways would significantly inhibit the growth of CNE-2 cell line,increase G1 arrest and reduce the expression levels of p-EGFR and COX-2." @default.
• W2351464009 created "2016-06-24" @default.
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• W2351464009 date "2009-09-01" @default.
• W2351464009 modified "2023-09-22" @default.
• W2351464009 title "[The effect of simultaneously blocking target epidermal growth factor receptor tyrosine kinase and cyclooxygenase-2 on the growth of NPC cell]." @default.
• W2351464009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20120857" @default.
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