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- W2351467359 abstract "Objective:To investigate the blood and synovial fluid levels of Th1,Th2 in patient with rheumatoid arthritis,the changeable features in arthritis duration and the significance to clinic.Methods:subcellular molecule IFN-γ and IL-4 were labeled in PBMC and SFMC from patients with rheumatoid arthritis and controls by immuno-fluorence staining method.Detection was performed by FACSCaliur.Result:The blood and synovial fluid number of IFN-γ+ cell and IFN-γ+/IL-4+ ratio in patients with rheumatoid arthritis was significantly higher compared with normal controls.In early rheumatoid arthritis individuals,the blood number of IFN-γ+ cell and IFN-γ+/IL-4+ ratio was significantly higher compared with normal controls,as for IL-4+ cells,it had been found in a higher level in not early rheumatoid arthritis individuals than in controls.We had also found the correlation between IFN-γ+ cell and ESR、morning stiffness、rest pain、STOKE index,IL-4+ cells and RF.Conclusion:The abnormal blood and synovial fluid levels of Th1/Th2 subset are observed in rheumatoid arthritis.The blood and synovial fluid of Th1 subtype is in predominance in early stage.As for IL-4+ cells,it has been found in a higher level in not early rheumatoid arthritis patients.Th1、Th1/Th2 have an important correlation to rheumatoid symptom and activity index.Medicine intervention to Th1/Th2 imbalance is a new clinic therapeutical way in rheumatoid arthritis." @default.
- W2351467359 created "2016-06-24" @default.
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- W2351467359 date "2008-01-01" @default.
- W2351467359 modified "2023-09-24" @default.
- W2351467359 title "Th Subset in Rheumatoid Arthritis and Clinic Significance" @default.
- W2351467359 hasPublicationYear "2008" @default.
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