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- W2351491438 abstract "Objective To compare the efficacy and adverse effects of bortezomib-dexamethasone-thalidomide(BDT) regimen with vincristine-epirubicin-dexamethasone-thalidomide(VEDT) regimen for multiple myeloma(MM). Methods A retrospective analysis was done in 72 MM patients,of whom,24(initial treatment 13 cases;recurrent and refractory 11) received BDT regimen;48(initial treatment 36;recurrent and refractory 12) treated with VEDT.All the patients were appraised after 4-6 courses of therapy,those who gave up the treatment,their course did not meet the criteria,and those failed to be followed were excluded from this study. Results The total complete remission rate(TR) of BDT and VEDT was 68.42% vs.35.42%;that of initial patients was 80.00% vs.44.44%;that of recurrent and refractory 55.56% vs.8.33%,the differences being significant between the two groups(χ2=3.965-5.996,P0.05).The total effective power was 89.47% for BDT,and 70.83% for VADT,with no significant difference between the two groups(P0.05).In BDT group,the new patients required three median cycles to reach the best response and in VEDT,five cycles were needed;for recurrent /refractory,three vs.five.Common adverse reactions of the two therapy programs were not significantly different,which included bone marrow depression,alimentary tract symptoms,damage of liver or renal function,peripheral neuropathy,fatigue,thrombosis,dysfunction of blood coagulation,herpes zoster,mental symptoms and rash. Conclusion BDT has a higher TR rate than VEAT in the treatment of MM,the efficacy is definite and rapid onset,the side effects are tolerable.BDT therapy is worth clinical generalization." @default.
- W2351491438 created "2016-06-24" @default.
- W2351491438 creator A5029660182 @default.
- W2351491438 date "2011-01-01" @default.
- W2351491438 modified "2023-09-26" @default.
- W2351491438 title "CLINICAL STUDY OF BDT AND VADT REGIMEN IN THE THERAPY OF MULTIPLE MYELOMA" @default.
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