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- W2351495891 abstract "Objective To explore the molecular mechanism of dysautoregulation of malformed cerebral vessels. Methods Total RNA was abstracted from 14 samples of arteriovenous malformations , and adjacent brain tissues and 8 normal cerebral vessels which were removed by microneurosurgery. The expressions of ppET - 1 and ETA receptor in AVMs were detected by RT - PCR. Results The expressions of ppET - 1 and ETA receptor mRNA in AVMs were lower than these in normal cerebral vessels. Conclusion Downregulation of expressions of ppET - 1 mRNA contributed to the lack of ET - 1 secretion in AVMs. Downregulation of ET - 1 has been implicated in a variety of vascular disorders involving both he-modynamic and structural changes in the vasculture. The decrease of ETA mRNA expression on AVM would prevent gene repression from exogenous sources of ET - 1 and reinforce the biological consequences of ET - 1 in AVMs,thus resulting in dysautoregulation of cerebral vessels in AVMs." @default.
- W2351495891 created "2016-06-24" @default.
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- W2351495891 date "2003-01-01" @default.
- W2351495891 modified "2023-09-28" @default.
- W2351495891 title "The Molecular Mechanism of Dysautoregulation of Malformed Cerebral Vessels" @default.
- W2351495891 hasPublicationYear "2003" @default.
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