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- W2351500427 abstract "OBJECTIVE:To study the inhibition effect of ethanol extract of chineve toad venom (EET) on H22 ascites and solid tumors and its toxicity in mice. METHODS: EET was prepared by decompress stilling and then injected intraperitoneally or subcutaneously into the mice bearing H22 ascites or solid tumors. The inhibition rates of tumor and the extended rate of life span in mice were calculated and the toxicity of EET was evaluated by biochemical parameters and pathological examination. RESULTS: The inhibition rate of tumor in mice bearing H22 solid tumors were 51.6% (t=2.346, P=0.028) and 41.2%(t=2.109, P=0.045) and the extended rate of life span in mice bearing H22 ascites tumors were 34.7%(t=3.346, P=0.002) and 27.7%(t=2.312, P=0.035) in mice receiving EET of 5 mg/kg and 0.5 mg/kg, respectively. EET of 0.5 mg/kg increased the number of white blood cells to (11.6±2.3)×10~9/L (t=3.326, P=0.002) and EET of 5 mg/kg increased the total bilirubin to (46.5±14.8) μmol/L (t=2.374, P=0.036). CONCLUSIONS: The results suggest that EET of 0.5 to 5 mg/kg could inhibit the growth of H22 ascites and solid tumors in vivo, but EET of 5 mg/kg may injure the liver of mice." @default.
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- W2351500427 date "2005-01-01" @default.
- W2351500427 modified "2023-09-25" @default.
- W2351500427 title "Inhibition effect of eethanol extract of Chinese toad venom on H22 ascites and solid tumors and its toxicity in mice" @default.
- W2351500427 hasPublicationYear "2005" @default.
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