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- W2351548045 abstract "Objective:To study the clinical effect and safety of preventive oral ibuprofen on patent ductus arteriosus in very low birth weight infant. Methods: 74 cases were divided into a preventive group of 32 cases with oral ibuprofen and a control group of 42 cases without oral ibuprofen unless the symptoms of patent ductus arteriosus appeared and/or were detected by the color doppler.Results: The closing rate in the prevention group was 90.62%,and in the control group was 78.57%.PDA was closed in 5 cases after treatment in 9 cases with PDA.At last,the closing rate in the control group was 90.47%,then the closing rate in the two groups had no significant difference(P0.05).In the prevention group,oliguria [urine output 1 mL/(kg·h)] occurred in 17 cases(53.13%) after the first dose,anuria in 2 cases and the medicine was stopped.Oliguria in the control group occurred in 6 cases(14.28%).The two groups had a significant difference(P0.05).Serum creatinine(71.67±(9.24)) in preventive group vs in the control group(73.26±9.53)(P0.05) on the 1st day in hospital showed no obvious difference,and(89.02±(21.86)) vs(69.12±11.35) (P 0.01) on the 4th day was an obvious difference.Two groups had no significant difference in necrotizing enterocolitis,gastric haemorrhage,intraventricular hemorrhage(IVH),chronic lung disease(CLD),death rate,and blood plate had,but the days of reaching full enteral feeding(FEF) and feeding intolerance(FI) had significant difference.Conclusions: The natural closing rate of patent ductus arteriosus was high in very low birth weight infant of 7~10days.Preventive group increased risk of organ injury in very low birth weight infant,but the treatment of oral ibuprofen was more rational and safe after patent ductus arteriosus appears." @default.
- W2351548045 created "2016-06-24" @default.
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- W2351548045 date "2006-01-01" @default.
- W2351548045 modified "2023-09-25" @default.
- W2351548045 title "The clinical study of preventive oral ibuprofen to patent ductus arteriosus in very low birth weight infant" @default.
- W2351548045 hasPublicationYear "2006" @default.
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