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- W2351561567 abstract "Objective To study the regularity and mechanisms of expression of platelet-activating factor receptor after rat focal ischemic middle cerebral artery occlusion/reperfusion.Methods 60 mature Wistar rats were randomly divided into twelve groups: sham-operated conrtol group, simple ischemia group, 6-hour (6 h), 12 h, 18 h, 24 h, 48 h, 3-day(3 d), 4 d, 5 d, 6 d, 7 d reperfusion groups. After the right middle cerebral artery occluded, the rats were suffered from ischemia for 90 minutes, then reperfusion was allowed for different time as mentioned above before decapitation. In sham-operated control rats, the thread inserted was only 9 millimeter long.Reverse transcription polymerase chain reaction(PCR) and radioimmunoassay were applied to evaluate the PAF receptor messenger RNA(mRNA) expression and PAF levels in rat ischemic brain tissue, respectively.Results RT-PCR analysis revealed that PAF receptor mRNA is the most abundant in rat brain of sham-control operated group. However, following ischemia-reperfusion, the levels of PAF receptor mRNA progressingly decreased untill 48 h reperfusion, then returned to sham-control group’s levels gradually. Compared with the control group’s, the PAF concentrations of simple ischemia and 6 h, 12 h, 24 h reperfusion group were significantly higher than that of any other groups. The PAF levels returned to basal values at 24 h.Conclusion These results indicate that PAF receptor gene expression may be subjected to down-regulation after focal cerebral ischemia and relative to increase of endogenous PAF concentrations." @default.
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- W2351561567 date "2002-01-01" @default.
- W2351561567 modified "2023-09-26" @default.
- W2351561567 title "Expression of platelet-activating factor receptor gene during focal reversible ischemia in rat brain" @default.
- W2351561567 hasPublicationYear "2002" @default.
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