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- W2351567190 abstract "Objective To evaluate the effects of pioglitazone,an insulin sensitizing agent,on serum matrix metalloproteinase-9(mmp-9)levels in patients with type 2 diabetes.Methods Type 2 diabetic patients(n=60) with mild vascular complication were divided as pioglitazone group(n=30) and control group(n=30) at random and in double-blind.The concurrently controlled clinical study was done about pioglitazone between pre-and post-12 weeks' treatment,and mmp-9 level was detected by ELISA method.Results(1)After 12 weeks' treatment,the level of mmp-9 in pioglitazone group was reduced by 19.8%,there was a significant difference compared with that before treatment(P0.01);but there was no significant difference in the level of mmp-9 between pre-and post-the treatment in the control group.(2)After 12 weeks' treatment,serurn insulin levels,fasting blood glucose,hemoglobin A1c,and fasting triglyceride decreased in pioglitazone group(P0.01).Conclusion Pioglitazone could reduce fasting serurn mmp-9 levels in type 2 diabetic patients and improve the vascular complications." @default.
- W2351567190 created "2016-06-24" @default.
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- W2351567190 date "2006-01-01" @default.
- W2351567190 modified "2023-09-23" @default.
- W2351567190 title "Effects of Pioglitazone on Serum Matrix Metalloproteinase-9 Levels in Patients with Type 2 Diabetes" @default.
- W2351567190 hasPublicationYear "2006" @default.
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