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- W2351574877 abstract "Objective To evaluate immunomodulatory effect of combined use ofulinastatin and thymosin α1 in patients with multiple organ dysfunction syndrome(MODS).Methods The patients with MODS were randomly divided into two groups,control group(15 cases) and treatment group(16 cases).In the control group,the patients were treated with regular therapy,and in the treatment group,the combined use of ulinastatin and thymosin α1 was added for 7 d.The acute physiology and chronic health evaluation(APACHE) Ⅱscore and MODS score based on Marshall standard(Marshall score) were calculated and hospitalization days in ICU and 28-day mortality were recorded.The concentrations of tumor necrosis factor alpha(TNF-α) and interleukin-6(IL-6) and the lymphocyte count were determined by enzyme-linked immunosorbent assay and the CD14+ monocyte human leukocyte antigen D-related(HLA-DR) expression was detected by flow cytometry before and after the treatment.Results No significant differences were found in the APACHE Ⅱand Marshall scores,the TNF-a and IL-6 levels,and the lymphocyte count between the treatment group and the control group before treatment(all P0.05).After 7 d treatment,the APACHE Ⅱscore in the treatment group was much lower,and the Marshall score was much higher than the control group(P0.05,P0.01,respectively).In the treatment group,lower levels of TNF-α and IL-6(all P0.05) and higher lymphocyte count(P0.01) were found on day 7 as compared to the control group.Patients in treatment group had significantly higher CD14+ monocyte HLA-DR expression than the control group on day 7(P0.05).The hospitalization days in ICU showed significant different between the two groups(P0.05),while the 28-day mortality did not(40% in the control group,37.5% in the treatment group,P0.05).Conclusion The therapy combined use of ulinastatin and thymosin α1 could improve the immune function and shorten the hospitalization daysin patients with MODS in some extent,but could not significantly reduce the 28-day mortality on the basis of the study result." @default.
- W2351574877 created "2016-06-24" @default.
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- W2351574877 date "2011-01-01" @default.
- W2351574877 modified "2023-09-24" @default.
- W2351574877 title "Clinical evaluation on immunomodulatory effect of combined use of ulinastatin and thymosin α1 in patients with multiple organ dysfunction syndrome" @default.
- W2351574877 hasPublicationYear "2011" @default.
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