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• W2351592339 abstract "Objective To survey the effects of 3 kinds of penetration enhancers,evodia rutaecarpa alkaloids,sinapine thiocyanate and berberine hydrochloride,on transdermal permeation of paeoniflorin in vitro,screen effective penetration enhancers and improve the transcutaneous permeability of paeoniflorin.Methods The abdomen skin of mice in vitro was taken as permeation barrier.The content of paeoniflorin was determined by using HPLC for studying the influences of 3 kinds of penetration enhancers on kinetic parameters of in vitro transdermal absorption of paeoniflorin including cumulative permeation quantity,transdermal absorption rate and transdermal time-lag within 12 h.Results The transcutaneous permeability of evodia rutaecarpa alkaloids,sinapine thiocyanate and berberine hydrochloride was,respectively,0.543 9 g/cm~2·h,0.993 0 g/cm~2·h and 3.709 9 g/cm~2·h,enhancing rate was,respectively,1.50,2.74 and 10.22,and transdermal time-lag was,respectively,2.10 h,1.12 h and0.34 h.Conclusion Evodia rutaecarpa alkaloids,sinapine thiocyanate and berberine hydrochloride can significantly improve the transdermal absorption of paeoniflorin." @default.
• W2351592339 created "2016-06-24" @default.
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• W2351592339 date "2014-01-01" @default.
• W2351592339 modified "2023-09-23" @default.
• W2351592339 title "Influences of different alkaloid penetration enhancers on transdermal absorption of paeoniflorin" @default.
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