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- W2351594258 abstract "Objective To explore the clinical significance of hydrogen sulfide(H2S)and heme oxygenase-1(HO-1)on pulmonary hypertension(PH),by detecting their levels of patients with congenital heart disease(CHD).Methods Forty-eight patients with CHD who had left-to-right shunt were selected randomly from cardiac surgery in the Fourth Hospital of Hebei Medical University.Forty-eight patients were performed successfully on radical operation under complex intravenous anesthesia,and they were divided 3 groups according to pulmonary artery systolic pressure(PASP)detected by doppler echocardiography before operation:no PH group(PASP3.990 kPa,n=15),mild PH group(PASP 3.990-6.517 kPa,n=15),mid-heavy PH group(PASP≥6.650 kPa,n=18).The radial artery blood specimens were collected immediately before operation,1 hour and 24 hours after operation.H2S in plasma was measured by optical absorbance method at 670 nm at each period.HO-1 activity in serum was measured by dual wavelength spectrophotometer at each period.The data were analyzed by repeated measures,multivariate ANOVA,and analysis of linear correlation.Results Plasma level of H2S of each group after ope-ration were higher than that of the same group before operation.Significant difference of the plasma level of H2S was found between 24 hours post-operation and pre-operation in the same group(Pa0.05).Whatever pre-operation,1 hour post-operation or 24 hours post-operation,the plasma level of H2S in the mid-heavy PH group and mild PH group were significantly lower than that in no PH group(Pa0.05),the plasma level of H2S in the mid-heavy PH group was significantly lower than that in mild PH group(Pa0.05).The HO-1 activity in serum of each group after operation was no obvious difference on statistics compared with that before operation;the HO-1 activity in serum was no obvious difference on statistics among the 3 group.There were negative correlation between PASP and the plasma levels of H2S of the 3 groups at pre-operation,1 hour and 24 hours post-operation(Pa0.01).There was no correlation between PASP and HO-1 activity in serum(Pa0.05).Conclusions H2S plays an important role in the formation of PH and restructure.There is no correlation between PASP and HO-1 activities in serum,but HO-1 may be play an indirect action in the formation of PH and restructure.Measuring the levels of H2S may be a reliable method to follow the change of pulmonary pressure and worsening of PH." @default.
- W2351594258 created "2016-06-24" @default.
- W2351594258 creator A5058907591 @default.
- W2351594258 date "2010-01-01" @default.
- W2351594258 modified "2023-09-27" @default.
- W2351594258 title "Changes of Hydrogen Sulfide and Heme Oxygenase-1 of Children with Congenital Heart Disease Combined with Pulmonary Hypertension and Those Significances" @default.
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