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- W2351614358 abstract "Objective To study the antioxidative effects of low molecular weight heparin nebulization on acute lung injury. Methods Twenty-four rabbits were randomly divided into control group,saline nebulization group and low molecular weight heparin nebulization group( n = 8 /group). Activity of superoxide dismutase( SOD) and glutathione peroxidase(GSH-Px),concentration of malondialdehyde(MDA),protein level of total Akt and p-Akt in lung tissue were detected. Results Compared with control group,activity of SOD and GSH-Px in saline nebulization group were significantly decreased(P 0. 05),concentration of MDA and protein level of total p-Akt in saline nebulization group were significantly increased(P 0. 05). In low molecular weight heparin nebulization group,activity of SOD and GSH-Px were significantly higher than that in saline nebulization group( P 0. 05),concentration of MDA and protein level of total p-Akt were significantly lower than that in saline nebulization group( P 0. 05). Conclusion Low molecular weight heparin nebulization may increase the activity of SOD and GSH-Px and decrease concentration of MDA in lung tissue of rabbits with acute lung injury. Low molecular weight heparin nebulization has antioxidative effects through the inactivation of PI3K /Akt signal pathway which may help to cure acute lung injury." @default.
- W2351614358 created "2016-06-24" @default.
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- W2351614358 date "2014-01-01" @default.
- W2351614358 modified "2023-09-25" @default.
- W2351614358 title "Antioxidative Effects of Low Molecular Weight Heparin Nebulization on Rabbit with Acute Lung Injury" @default.
- W2351614358 hasPublicationYear "2014" @default.
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