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- W2351615717 abstract "Objective To evaluate the expression of T cell immunoglobulin domain and mucin domain-1(TIM-1),an atopy susceptibility gene,in T helper lymphocytes in patients with allergic rhinitis(AR).Methods Human peripheral blood mononuclear cells(PBMC) were separated by density gradient from 25 healthy individuals and 25 AR patients.Magnetic cell sorting technique(MACS) was applied to purify CD4+ T cells and CD4+CD45RA+ T cells.Immunofluorescence staining and flow cytometry were used to detect the T helper lymphocyte marker TIM-1.The rates of TIM-1 positive T helper lymphocytes before and after non-specific stimulation with PHA(20 μg/ml) were compared between AR patients and healthy controls.Results The rate of TIM-1 positive CD4+ T cells was(9.5±1.51)% in AR patients compared with(3.1±0.3)% in healthy controls(P0.05),both of which were increased with PHA stimulation(P0.05).Conclusion The higher rate of TIM-1 positive T helper lymphocytes found in AR patients suggested that TIM-1 expression in T helper lymphocytes may promote differentiation of T helper lymphocytes,and thus have a role in the immune responses of AR patients." @default.
- W2351615717 created "2016-06-24" @default.
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- W2351615717 date "2008-01-01" @default.
- W2351615717 modified "2023-09-23" @default.
- W2351615717 title "T cell immunoglobulin domain and mucin domain-1 expression of T lymphocytes in allergic rhinitis" @default.
- W2351615717 hasPublicationYear "2008" @default.
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