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- W2351619658 abstract "Objective To evaluate the expression of transforming growth factor-beta 1 (TGF-β1) in cartilage of rabbit mandibular condyle after anterior disc displacement (ADD).Methods Twenty-two healthy adult Japanese rabbits weighing from 2.5 to 3 kg were used in this study. Sixteen rabbits were subjected to surgical anterior disc displacement in the right temporomandibular joints, every 4 rabbits were sacrificed 1, 2, 4, 8 weeks post-operation, 4 rabbits were used as sham-operative control and the other two without operation were used as normal control. The expressions of TGF-β1 in cartilage of mandibular condyle were studied by S-P immunohistochemical staining.Results Experimental and sham-operative animals tolerated the surgical procedures well. The discs displaced anteriorly were observed successfully in the experimental rabbits by general and microscope observation. In control group, TGF-β1 was mostly expressed in the hypertrophic cartilaginous layer and calcified cartilaginous layer. After anterior disc displacement, the TGF-β1 expression in transitional layer and proliferative layer was increased. In 8 weeks group after ADD, cells in all layers of mandibular condyle almost expressed TGF-β1.Conclusion After ADD, the expression of TGF-β1 in mandibular condyle changed, which was consistent with the process of ADD developed.It suggested that TGF-β1 might regulate the remodeling of the mandibular condyle induced by the mechanical stimulation in the disc displacement process." @default.
- W2351619658 created "2016-06-24" @default.
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- W2351619658 date "2005-01-01" @default.
- W2351619658 modified "2023-09-27" @default.
- W2351619658 title "TGF-β1 Expression in Cartilage of Rabbit Mandibular Condyle after Anterior Disc Displaced" @default.
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