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- W2351626443 abstract "[Objective] To explore the expression and significance of PTEN and TGFβ1 proteins in cervical cancer, cancer in situ and normal cervical. [Methods] Fifty-six cases with cervical cancer, twenty-four cases with cancer in situ and twenty cases with normal cervical were tested for the expression of PTEN and TGFβ1 proteins by Envision immunohistochemistry. [Results] The expression of PTEN and TGFβ1 on cervical cancer was significantly lower than those of normal cervical and cancer in situ groups (χ2 = 18.76, P﹤0.01; χ2 = 15.04, P﹤0.01). The expression of PTEN was significant difference with that in cancer in situ, stage I-II and stage III (P﹤0.05). There was significant difference between cervical cancer higher and moderate lower differentiation degree and lymphnode metastasis (P﹤0.05), The expression of TGFβ1 protein was not significant difference among cancer in situ、 stageIII and stage III and differentiation degree (P﹥0.05), There was significant difference between cervical cancer with and without lymphnode metastasis (P ﹤ 0.05). [Conclusion] This study showed that PTEN negative expression was association with the generation and development of cervical cancer. The positive expression of TGFβ1 was associated with invasion and metastasis. Detection on expression of PTEN and TGFβ1 may play an important role in early diagnosis and predict the prognosis of cervical cancer." @default.
- W2351626443 created "2016-06-24" @default.
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- W2351626443 date "2009-01-01" @default.
- W2351626443 modified "2023-09-25" @default.
- W2351626443 title "EXPRESSION AND SIGNIFICANCE OF PTEN AND TGFB-1 PROTEINS IN CERVICAL CANCER" @default.
- W2351626443 hasPublicationYear "2009" @default.
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