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- W2351637293 abstract "Monoamine oxidase B(MAOB) is one of flavin-dependent enzymes,which is constructed by 520 amino acids.It binds to the mitochondrial outer-membrane through a C-terminal transmembrane helix.MAOB gene is located at X chromosome and its core promoter is located at-246/-99.MAOB gene expression is modulated by several factors.It can convert dopamine to DOPAC and produce hydrogen peroxide.MAOB gene knock-out mice are resistant to the neurotoxin,1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.MAOB is distributed in the special cerebral regions.The activity of MAOB is detected to increase in many kinds of neurodegenerative diseases.It may be involved in modulation of the oxidative stress and process of neurodegenerative diseases." @default.
- W2351637293 created "2016-06-24" @default.
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- W2351637293 date "2006-01-01" @default.
- W2351637293 modified "2023-09-26" @default.
- W2351637293 title "Monoamine oxidase B— the possible target for the treatment of neurodegenerative diseases" @default.
- W2351637293 hasPublicationYear "2006" @default.
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