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- W2351639632 abstract "Objective:To prepare the hydrogel-matrix sustained-release tablets of the antiepileptic drug levetiracetam(LEV),and to investigate the stability of the tablets.Methods:The preparation process of LEV sustained-release tablets was optimized by investigating the type and amount of hydroxypropylmethyl cellulose(HPMC),preparing methods,as well as the hardness of the tablets.The stability of the tablets was studied under different conditions,such as high humidity,high temperature and strong light exposure,by taking appearance,weight gain,the LEV content and LEV release rate as indexes.Results:The optimized preparation process of LEV sustained-release tablets was confirmed as follows:K15M was selected as skeletal material,with the LEV-K15M ratio of 3 ∶1;the wet granulation method was used to press the tablets,with the hardness of 16-17 kg.The LEV sustained-release tablets have good and similar release profile in dissolution medium of different pH values.The tablets were stable to the strong illumination and high temperature,while their coating membranes would wrinkle under high humidity.Conclusion:The preparation process of LEV sustained-release tablets is simple and the quality can be controlled,which meets the requirement for large scale production." @default.
- W2351639632 created "2016-06-24" @default.
- W2351639632 creator A5006141258 @default.
- W2351639632 date "2011-01-01" @default.
- W2351639632 modified "2023-09-27" @default.
- W2351639632 title "Study on Preparation and Stability of Levetiracetam Sustained-Release Tablets" @default.
- W2351639632 hasPublicationYear "2011" @default.
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