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- W2351659931 abstract "Objective In order to demonstrate whether donor specific blood transfusion induces tolerance in murine xenografting. Methods We first studied effect of xenogenic blood transfusion on visceral functions of rats. In this study, human, pig and guinea pig were used as blood donors and the outbred wistar rats as the recipients. Forty five recipient rats transfused with human blood were randomly divided into group Ⅰ,Ⅱand Ⅲ. The total human blood volume for group Ⅰ,ⅡandⅢ were 1ml, 6ml and 10ml, respectively. One ml blood in volume was adminstered to one rat via the vein each day and the rat survival, the serum values of PaO 2, PaCO 2, A aDO 2, GPT,GOT,TP, LDH,BUN and Cr as well as the pathological changes of heart,liver,lung,kidney,spleen,stomach and the vascularity of the rats before and after human blood transfusion were evaluated;whereas the rats transfused with pig and guinea pig blood were used for observing their survivals only. Results All rats survived well after transfusion with human. Pig and guinea pig blood, there were no statistical difference about both the serum values of PaO 2, PaCO 2, A aDO 2, GPT, GOT, TP, LDH, Cr, BUN( P 0 05) and the pathological changes of heart, liver, kidney, lung, spleen, vascularity, stomach of the rats before and after human blood transfusion. Conclusions These results indicated that xenogenic blood transfusion did not affect rat survival and visceral functions and could be used to study xenogenic tolerance induction in murine xenotransplantation." @default.
- W2351659931 created "2016-06-24" @default.
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- W2351659931 date "1999-01-01" @default.
- W2351659931 modified "2023-09-24" @default.
- W2351659931 title "Effect of xenogenic blood transfusion on visceral functions of rats" @default.
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