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- W2351664064 abstract "Objective: To investigate the effects of Glycyrrhiza uralensis Fisch.(Gancao) on the activity and mRNA expression of drug metabolic enzyme CYP3 A in rat liver, and evaluate the effect of Gancao. on the metabolism of diester-type aconitine alkaloids in rat liver microsomes in vitro. Methods: SD male rats were randomly divided into control, group enzyme inducer group, Gancao low, medium and high dose group. The rat livers were used to prepare the liver microsomes with incubation in vitro. Microsomal CYP3 A activity was quantified by HPLC. Meanwhile, the expression of CYP3A1/2 mRNA was detected by RT-PCR. And the metabolic changes of diester-type alkaloids incubated in rat liver microsomes were measured. Results: The activity of CYP3 A induced by Gancao was in accordance with mRNA expression of CYP3 A in rat. The metabolic rates of diestertype aconitine alkaloids induced by the Gancao medium dose group were signfiicantly higher than those by the control group, as well the Gancao low dose group, but that were inferior to the Gancao medium dose group. There were no signfiicant dif erences in the metabolic rates induced by the Gancao medium high group and the control group. Conclusion: With the compatibility of Gancao and Aconitum carmichaelfiiDebx. Gancao could accelerate the metabolism of aconitine, mesaconitine and hypaconitine in vitro." @default.
- W2351664064 created "2016-06-24" @default.
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- W2351664064 date "2014-01-01" @default.
- W2351664064 modified "2023-09-23" @default.
- W2351664064 title "Antitoxin compatible mechanism of Glycyrrhiza uralensis Fisch. inducing CYP3A to promote the metabolism of Aconitum carmichaelii Debx." @default.
- W2351664064 hasPublicationYear "2014" @default.
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