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- W2351666520 abstract "OBJECTIVE:To detect the expressions of leptin and Ob-R in breast cancer,and explore their clinical significance.METHODS:By immunohistochemical methods the expressions of leptin and Ob-R were detecled in 60 cases of breast cancer,30 cases of benign breast lesions and 30 cases of normal breast tissue.RESULTS:The difference of the expressions of leptin and Ob-R was statistically significant between the breast cancer and benign breast lesions(P1=0.000;P2=0.000),and so was the difference between the breast cancer and adjacent cancer tissues(P1=0.000;P2=0.000).No significant difference was observed in benign breast lesions and adjacent cancer tissues(P1=0.169;P2=0.545).There were statistically significan differences between the breast cancer with and without lymph node metastasis(P=0.036),and leptin and Ob-R expressions were positively correlated with the different TNM stages of breast cancer(P1=0.021,r1=0.297;P2=0.007,r2=0.342).CONCLUSIONS:Leptin can be regarded as a marker for diagnosis of breast cancer,and can be used for judging the stage and prognosis of breast cancer.It provides a new idea in the treatment of breast cancer." @default.
- W2351666520 created "2016-06-24" @default.
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- W2351666520 date "2008-01-01" @default.
- W2351666520 modified "2023-09-24" @default.
- W2351666520 title "Expressions of leptin and leptin receptor in breast cancer and their clinical significance" @default.
- W2351666520 hasPublicationYear "2008" @default.
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