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- W2351677114 abstract "Objective:To establish a sensitive ultraperformance liquid chromatography(UPLC) method for determining the plasma concentration of paeonol in liver cancer model rat and to evaluate its pharmacokinetic characteristics.Method: Rats were divided into three groups,a single ig dose of 259.2,194.4,129.6 mg · kg-1 paeonol was given respectively.Paeonol was separated on a C18 column with methanol:water(70∶30) as mobile phase.The plasma concentration of paeonol was determined and its pharmacokinetic parameters were calculated by using WinNonlin 5.2.1.Result:The linear range of the method for paeonol was 0.323-41.4 mg · L-1.The plasma concentration-time course showed two compartment model,with the increased dose,AUC,Cmaxhas a significant increase,while Tmax,T1/2β,CL have no significant change.Conclusion:The UPLC method for determining paeonol concentration in plasma is simple,rapid,sensitive and suitable for pharmacokinetic study.There are some differences between pharmacokinetic parameters in liver cancer model rats with different dose of paeonol." @default.
- W2351677114 created "2016-06-24" @default.
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- W2351677114 date "2012-01-01" @default.
- W2351677114 modified "2023-09-28" @default.
- W2351677114 title "Pharmacokinetic Study of Paeonol in Liver Cancer Model Rat" @default.
- W2351677114 hasPublicationYear "2012" @default.
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