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- W2351678024 abstract "Aim: To evaluate the predictive value of detecting ERCC1 mRNA in esophageal cancer tissue on chemotherapy efficacy .Methods: Twenty patients with esophageal cancer who had not received any treatment before accepted two cycles chemothereapy of cisplatin and fluorouracil combination. ERCC1 mRNA level in esophageal tumor tissue was detected by semi-quantitative RT-PCR before chemotherapy.The relationship between chemotherapy efficacy and ERCC1 mRNA level in esophageal cancer tissue before chemotherapy was analyzed.Results: The median ERCC1 mRNA level was 0.956(ranging from 0.37 to 1.61). The mean ERCC1 mRNA level of 11 responding patients was 0.799, whereas that of non-responding patients was 1.147(P0.05).The ERCC1 mRNA level was negatively correlated with chemotherapy efficacy( r s=-0.515, P=0.02).Conclusion: The predictive value of detecting ERCC1 mRNA level in esophageal cancer on chemotherapy efficacy before chemotherapy is valuable to further study." @default.
- W2351678024 created "2016-06-24" @default.
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- W2351678024 date "2005-01-01" @default.
- W2351678024 modified "2023-09-26" @default.
- W2351678024 title "Predictive value of detecting ERCC1 mRNA in esophageal cancer tissue on chemotherapy efficacy" @default.
- W2351678024 hasPublicationYear "2005" @default.
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