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- W2351681422 abstract "Objective To investigate the dynamic expressions of angiopoietin 1(Ang-1)and its receptor Tie-2 in acute β-ray-irradiated skin injury.Methods Fifty-four female SD rats were divided into 3 groups.The models of acute β-ray-irradiated skin injury were established by radiation with 45 Gy β-ray on the skin in 24 rats(group A).The models of deep second degree burn were established by electrical scald instrument with constant temperature 80℃,8 s and 25 mm as common traumatogenic factors in 24 rats(group B).Six normal rats were served as normal controls(group C).The expressions of Ang-1 and Tie-2 proteins and Ang-1 mRNA and Tie-2 mRNA were semi-quantitatively checked by immunohistochemical SP technique and RT-PCR,respectively at 1,2 and 3 weeks after radiation.Results Lower expressions of Ang-1 and Tie-2 proteins were identified in rat skin in group C.The Ang-1 absorbance values of 1,2 and 3 weeks in group A were 0.130±0.012,0.170±0.013 and 0.192±0.072,which were lower than 0.190±0.182,0.332±0.014 and 0.273±0.014 in group B(P0.05).The Tie-2 absorbance values of 1,2 and 3 weeks in group A were 0.112±0.011,0.183±0.012 and 0.171±0.061,which were lower than 0.170±0.062,0.310±0.013 and 0.284±0.014 in group B(P0.05).The changes of Ang-1 mRNA and Tie-2 mRNA were similar to those of Ang-1 and Tie-2 proteins.Conclusion The persisting lower expressions of Ang-1 and Tie-2 may be one of the mechanisms involved in the of retarded healing of acute β-ray radiation injured skin wounds." @default.
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- W2351681422 date "2012-01-01" @default.
- W2351681422 modified "2023-09-26" @default.
- W2351681422 title "Expressions of angiopoietin 1 and its receptor in acute .BETA. irradiated skin injury in rats" @default.
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