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- W2351682992 abstract "The membrane form of CD28 in T cells and the serum level of soluble CD28 from peripheral blood of elders(beyond age of 60) were analysed in order to clarify its significance in the changes of immune functions in elders.The methods for detecting the membrane CD28 in T cells and the levels of sobuble CD28 in peripheral blood were FACS analysis and ELISA assay respectively.Meanwhile,the changes on positive rates of membrane CD28 and the concentrations of soluble CD28 along with the change in age and sex were analysed with statistics.It was found that the expression rates of membrane CD28 in T cells of elders were 41.56%±11.23% in male and 42.97±12.025 in female respectively compared with those of young men(61.51±(17.45%)) and young women(62.38%±16.22%),it showed significant differences.As demonstrated by ELISA assay,compared with the concentrations of serum soluble CD28 in male elders(1.08±0.45)ng/ml and female elders(0.98±0.47)ng/ml as well as young men(0.55±0.16)ng/ml and young women(0.52%±0.13%),significant differences also existed.It is evident that in case of elders the expression of menbrane CD28 in T cells reduces,while the serum level of soluble CD28 elevates significantly." @default.
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- W2351682992 date "2007-01-01" @default.
- W2351682992 modified "2023-09-26" @default.
- W2351682992 title "Expression and its significance of the membrane CD28 in T cells and the serum level of soluble CD28 in elders" @default.
- W2351682992 hasPublicationYear "2007" @default.
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