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- W2351717100 abstract "Objective To determine scutellarin in rat plasma after ig.administration of Dengzhanshengmai extracts(traditional Chinese medicines).Methods The plasma samples were prepared using a liquid-liquid extraction.Rutin was used as the internal standard.A C18 column was used,with the mobile phase of acetonitrile-0.05%(φ)phosphoric acid(V∶V=65∶320)at the flow rate of 1.0 mL·min-1,at the detection wavelength of 335 nm,column temperature of 40 ℃.Results The calibration curve of scutellarin was linear in the concentration range of 0.05-5.00 mg·L-1(r=0.997 9).The lower limit of quantification was 0.05 mg·L-1.The RSDs of inter-and intra-day were less than 15%.The average extraction recoveries were(81.6±3.6)%,(79.2±3.0)%and(78.7±2.4)%at concentrations of 0.1,0.5 and 4.0 mg·L-1,respectively.The main pharmacokinetic parameters were as follow:ke=(0.269±0.035)h-1,t1/2=(2.61±0.36)h,AUC0-24=(25.272±5.682)mg·h·L-1.Conclusions This method is suitable for the study of the pharmacokinetics of scutellarin from Dengzhanshengmai extracts." @default.
- W2351717100 created "2016-06-24" @default.
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- W2351717100 date "2010-01-01" @default.
- W2351717100 modified "2023-09-23" @default.
- W2351717100 title "Determination of scutellarin from dengzhanshengmai extracts in rat plasma by RP-HPLC" @default.
- W2351717100 hasPublicationYear "2010" @default.
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