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- W2351729752 abstract "Objective: To investigate the relationship between the of c-Jun N-terminal kinase(JNK) pathway and Akt and MKP Methods: Rats in the experimental group were subjected to four-vessel occlusion method,endured 10 min ischemia followed by reperfusion for 15min,1h,4h and 24h to examine phosphorylation of JNK and its upstream Akt in the rat hippocampi.The PI3K inhibitor LY294002 and MAPK phosphatase inhibitor cycloheximide were administrated to the rat hippocampi to observe the change of JNK activity.Results: JNK activity at 4h was enhanced obviously,which suggested that activated Akt suppresses the JNK pathway.Moreover,the JNK activity at 4h was also largely enhanced by cycloheximide,which indicated that the inactivation of JNK by phosphatases occurs at about 4 h via its dephosphorylation.Conclusion: Both Akt and MAPK phosphatase negatively regulate JNK pathway during cerebral ischemia in rat hippocampi." @default.
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- W2351729752 date "2011-01-01" @default.
- W2351729752 modified "2023-09-26" @default.
- W2351729752 title "Relationship Between Akt and MAPK Phosphatase and Activity of c-Jun N-terminal Kinase in Rats after Cerebral Ischemia Reperfusion" @default.
- W2351729752 hasPublicationYear "2011" @default.
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