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- W2351749596 abstract "Objective To evaluate the roles of the cannabinoid receptor type 1(CB1) and extracellular-signal regulated kinase(ERK) in hepatic fibrosis.Methods A rat model of hepatic fibrosis was generated by intraperitoneal injection of 10% carbon tetrachloride.Liver tissues and serum samples were collected at post-injection weeks 2,4,6,and 8.Histopathological changes were detected by hematoxylin-eosin staining.Changes in mRNA levels of CB1 and ERK were determined by quantitative reverse transcription-polymerase chain reaction.Biochemical assays were used to detect changes in serum alanine aminotransferase(ALT) and aspartate aminotransferase(AST) levels,and radioimmunoassay was used to determine changes in serum hyaluronic acid(HA) level.Results Compared with the uninduced,non-fibrotic control group,the mRNA levels of CB1 and ERK were significantly higher in the fibrotic group at all times examined(all P0.05).Moreover,the levels of CB1 and ERK mRNA,and serum ALT,AST and HA significantly increased over time(all factors,all time points P0.05).The CB1 mRNA level in liver tissue was correlated with the levels of serum ALT,AST,and HA(r=0.741,0.763,0.769,respectively;all P0.01) and with ERK mRNA in liver tissue(r=0.789,P0.01).Conclusion CB1 may promote the activation of ERK in rats with hepatic fibrosis,and may induce hepatic stellate cell proliferation via ERK signal transduction to promote progression of liver fibrosis." @default.
- W2351749596 created "2016-06-24" @default.
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- W2351749596 date "2012-01-01" @default.
- W2351749596 modified "2023-09-24" @default.
- W2351749596 title "CB1 and ERK gene expression in liver tissue of rats with experimental hepatic fibrosis" @default.
- W2351749596 hasPublicationYear "2012" @default.
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