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- W2351766268 abstract "Objective To evaluate the anti-cancer activity of Epothilone B on human breast cancer MCF-7 both in vivo and in vitro.Methods According to Principles of Preclinical Evaluation,the anti-cancer activity of Epothilone B in vitro was inspected by MTT method,while the activity in vivo was evaluated by observing the growth inhibition of MCF-7 xenograft tumors.Results The replicated MTT inspection showed that the IC50 of Epothilone B was both 1.7762 nmol/L and 0.8578 nmol/L.The maximum growth inhibition rate was 72.24% and 86.94%.The IC50 of paclitaxel was 2.0627 nmol/L and 1.9807 nmol/L respectively and the maximum inhibition rate was 70.98% and 86.86% respectively.According to the observation of MCF-7 xenograft tumors,Epothilone B produced dose-dependent inhibition.The result of the first experiment showed the inhibition rate of Epothilone B with at a single dose of 8,6,4 mg/kg and 2 mg/kg was 85.8%,85.1%,83.7% and 48.3% respectively.The finding of the second experiment was that the inhibition rate of Epothilone B at a single dose of 6,4 mg/kg and 2 mg/kg was 86.9%,77.8% and 37.5% respectively.During the observation,a few of the nude mice died and had a transient weight reduction.Compared with Epothilone B,the inhibition rate of paclitaxel at a multiple dose of 15 mg/kg was 98.9% and 97.3%.Conclusion Epothilone B can efficiently inhibit the growth of human breast cancer MCF-7 both in vivo and in vitro." @default.
- W2351766268 created "2016-06-24" @default.
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- W2351766268 date "2011-01-01" @default.
- W2351766268 modified "2023-09-22" @default.
- W2351766268 title "Anti-cancer Evaluation of Epothilone B on Human Breast Cancer MCF-7" @default.
- W2351766268 hasPublicationYear "2011" @default.
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