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- W2351776064 abstract "Aim To investigate the apoptotic effect and mechanism of δ-elemene on Colorectal Adenoarcinoma Cells DLD-1 in vitro.Methods Cell proliferation was measured by MTT method.Cell DNA fragmentation was quantitatively assessed by ELISA assay.The levels of detectable phosphatidylserine(PS)externalization were quantified using flow cytometry by Annexin V FITC kit.Gene expressions of Bax,cytochrome C,pro-caspase-3 and AIF were determined by Western blot analysis.Results δ-elemene inhibited the proliferation of DLD-1 cell significantly.The apoptosis of DLD-1 cells was further confirmed and quantified by DNA fragmentation ELISA and Annexin V(AnV)binding of externalized PS using flow cytometry.In the process ofthe induction of apoptotic cell death,Bax translocated into mitochondria,a release of cyto C and apoptosis inducing factor(AIF)from mitochondria into the cytosol occurred,δ-elemene activated the caspase-signaling pathway,leading to the proteolysis conversion of pro-caspase-3 to activate caspase-3,and the subsequent cleavage of the caspase substrate PARP.Conclusion DLD-1 cell death by δ-elemene is through a mitochondrial-mediated pathway." @default.
- W2351776064 created "2016-06-24" @default.
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- W2351776064 date "2010-01-01" @default.
- W2351776064 modified "2023-09-23" @default.
- W2351776064 title "Cell apoptosis induced by δ-elemene in colorectal adenoarcinoma cells via mitochondrial-mediated pathway" @default.
- W2351776064 hasPublicationYear "2010" @default.
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