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- W2351783504 abstract "OBJECTIVE:To investigate the protective effect of MnTBAP on radiation-induced lung injury in the rats model.METHODS: Male SD rats were divided into three groups:control group,radiation injured group,and MnTBAP treated group.lung injury models were made by putting the rats under the exposure of 6 MV X-ray at a dose of 28 Gy thoracically.Then the normal saline was injured intraperitoneally immediately of those rats in the injured group,while,all other things equal,MnTBAP(10 mg/kg) was injected to the treated group.After 1,4,8 and 12 weeks,using biochemical methods to test the superoxide dismutase(SOD),malondialdehyde(MDA),anti-superoxide anion radicals(ASAR) activity,hydroxyproline(Hyp) and the serum of transforming growth factor-β1(TGF-β1) level.RESULTS: When comparing these two groups,the pathological test shows that the injury level of MnTBAP group was much slighter than that of injured group.Meanwhile,biochemical test result shows that the content of SOD increased notably after 1 to 12 weeks time(all P0.001),in addition the ASAR incresed significantly too(all P0.001).On the contrary,the amount of MDA significantly decreased(1 week,P0.001;4-12 weeks,all P0.05),the amount of TGF-β1 significantly decreased(all P0.001).Moreover,the Hyp,stayed at the same level for the first 4 weeks but reduced significantly during 8-12 weeks(8 weeks,P0.05;12 weeks,P0.01).CONCLUSIONS: MnTBAP has the function of-antioxidant and the function of eliminating the free radical.It also has the protecting function to radiation-induced lung injury.In this case,it may be a potential radio-protector." @default.
- W2351783504 created "2016-06-24" @default.
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- W2351783504 date "2012-01-01" @default.
- W2351783504 modified "2023-09-28" @default.
- W2351783504 title "Protection effect of MnTBAP on acute radiation-induced lung injury in rats" @default.
- W2351783504 hasPublicationYear "2012" @default.
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