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- W2351792957 abstract "Objective To explore chronic hepatitis B virus(HBV)infected serum hepatitis B virus nucleic acid related antigen(HBV NR Ag)testing in the clinical application value.Methods Selection of chronic HBV infection in 292 cases(male 158 cases,female 134 cases),fasting venous blood was collected.Using enzyme-linked immuno-sorbent assay(ELISA) to detect serum antigen of HBV nucleic acid related subjects and former S1 antigen(PreS1Ag);Chemiluminescence method to detect HBV marker(HBsAg,HBsAb,HBeAg,HBeAb,HBcAb) content;Real-time fluorescent quantitative PCR technique to detect the contents of HBV-DNA;The Hitachi 7600 bio-chemical analyzer test in patients with liver function index[alanine aminotransferase(ALT),aspartate aminotransferase(AST),total bilirubin(TBIL),total protein(TP),albumin(propagated)],the results for statistical analysis.Results Two hundrend and ninetytwo cases of chronic HBV infection,HBV NR Ag,HBeAg,PreS1Ag and HBVDNA positive patients with positive coincidence rate was 96.7%,45.3%,73.5%.Regardless of the pattern of HBeAg,HBeAb and HBV DNA(+)patients NRAg positive rate had no statistical difference(P0.05).The expression of HBV NR Ag was positively associated with HBVDNA copy number(r=0.915 5,P0.05),HBeAg and PreS1Ag results with HBV DNA had significant statistical difference(P0.01).ALT,AST levels of HBV NR Ag positive patients was obviously higher than that of HBV NR Ag negative patients(P0.05).Conclusion HBV NR Ag associated with virus replication,and highly related to the level of HBVDNA and participate in the injury of liver cells,is monitoring HBV replication and antiviral effect of a new indicator." @default.
- W2351792957 created "2016-06-24" @default.
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- W2351792957 date "2013-01-01" @default.
- W2351792957 modified "2023-09-24" @default.
- W2351792957 title "Chronic hepatitis B virus infection of hepatitis B virus associated antigen nucleic acid detection value of clinical application" @default.
- W2351792957 hasPublicationYear "2013" @default.
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