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- W2351798595 abstract "Objective To probe into probable indicator of airway remodeling in asthma. Methods The guinea pig model of airway remodeling in asthma was established by the use of OVA.Forty guinea pigs were divided into 4 groups:the normal control group,the asthma 10-week group,16-week group and 20-week group.For each group,Na~+,Cl~-,pH,PaO_2,PaCO_2,AB,SB in serum,and thickness of airway wall were measured and compared with each other.Results ①According to thickness of airway wall,the order was: the 20-week groupthe 16-week groupthe 10-week groupthe normal control group(P0.01).②PaO_2 in the asthma model group was lower than that in the normal control group(P0.01).For pH,PaO_2,AB and SB,the order was: the 20-week groupthe 16-week groupthe 10-week group(P0.01).But for PaCO_2,the order was:the 20-week group the 16-week groupthe 10-week group(P0.01).③There was a negative correlation between the PaO_2、pH and the wall thickness of the airway(P0.01),while a positive correlation between the PaCO_2,AG and the wall thickness of the airway(P0.01).Conclusion Blood-gas content may be regarded as a probable indicator of asthmatic airway remodeling,the decrease of PaO_2 may be a primary indicator." @default.
- W2351798595 created "2016-06-24" @default.
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- W2351798595 date "2005-01-01" @default.
- W2351798595 modified "2023-09-28" @default.
- W2351798595 title "Study of indicator of airway remodeling in asthma" @default.
- W2351798595 hasPublicationYear "2005" @default.
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