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- W2351806135 abstract "Objective To evaluate safety of multivalent Aβ1-15 peptide gene engineering vaccine(4×Aβ1-15)in rhesus monkeys.Methods Four experimental adult rhesus monkeys were received intramuscular injections with 4×Aβ1-15 vaccine for four times,and the intermission was two weeks.The general examination of blood and hepatorenal function in rhesus monkeys were proceeded before and after vaccination.Pathological examination of brain,liver,spleen and kidney was observed.Systematic reaction and local reaction were observed during vaccination each time.Results There was no adverse local and systematic reaction appearing in the rhesus monkeys after vaccination with 4×Aβ1-15.The results of determination of haematology and hepatorenal funcion showed that all data were in the normal range and had no distinct difference whenever before the first vaccination or after the fourth vaccination(P0.05).Furthermore,there were no pathological changes in microstructure of brain,liver,spleen,kidney of the rhesus monkeys with vaccination and there was non-hemorrhage in brain.Conclusion Multivalent Aβ1-15 peptide gene engineering vaccine(4×Aβ1-15)has favourable safety." @default.
- W2351806135 created "2016-06-24" @default.
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- W2351806135 date "2008-01-01" @default.
- W2351806135 modified "2023-09-23" @default.
- W2351806135 title "Safety of multivalent Aβ1-15 peptide gene engineering vaccine on rhesus monkeys" @default.
- W2351806135 hasPublicationYear "2008" @default.
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