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- W2351808168 abstract "Objective To study the effect of mechanical stretch on the morphology,arrangement and migration of bone mesenchymal stem cells(BMSC) in vitro.Methods After BMSC were stimulated by mechanical strain,the cellular morphology,distribution,alignment and migration were observed by contrast phase microscope and quantitatively analyzed by computer image processing.Results After mechanical stretch treatment,spindle shape of cells elongated and the cells gradually arranged along the tangent direction of stress.After intervention to BMSC by 12 % strain for 12 and 24 hours,the length of cells increased 1.56-time and 1.66-time,the cell angle between tangent lines was 9.48° ± 2.83°,8.30° ± 6.03°,and proportion of cell angles lied in less 10° between the tangent line were 88.52 % ± 6.43 %,92.33 % ± 4.98 % respectively,those were significantly higher than that in control group.Furthermore,there was an increase in cell migration.Conclusion The changes of cell configuration,arrangement and migration are obvious,it is demonstrated that there is a stress reaction integration process after BMSC stimulated by mechanical strain." @default.
- W2351808168 created "2016-06-24" @default.
- W2351808168 creator A5062400619 @default.
- W2351808168 date "2011-01-01" @default.
- W2351808168 modified "2023-09-26" @default.
- W2351808168 title "Effect of mechanical stretch on morphology,arrangement and migration of bone mesenchymal stem cells in vitro" @default.
- W2351808168 hasPublicationYear "2011" @default.
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