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- W2351808630 abstract "[Objective] To explore the apoptosis of hepatocytes during the ischemia reperfusion (IR), compared with which controlled by ischemic preconditioning(IP). [Method] The rabbits were randomly divided into sham-operation(so), IR group and IP group. The latter two groups were farther divided into 6 subgroups and subjected to 60 minutes of ischemia. IP was achieved by ischemia for 5 minutes, followed by reperfusion for 5 minutes. In SO group, the rabbits were killed 24 hours after the operation and liver tissues were sampled. All groups' apoptosis index(AI) were cauculated. [Results] AI significantly increased in IR3h~24h groups, compared with IP3h~24h groups (P 0.01), and the different of which was no significant between IR1h, 48 h groups and IP1h, 48 h groups. In the interior of IR groups, from the IR1h to IR24h groups, AI was significantly elevated compared with the precedent group (P 0.01, P 0.05), while the AI of IR48h group was significantly decreased compared with the other IR groups (P 0.01). In the interior of IP groups, compared with other subgroups, AI of IR1h group is significantly difference (P 0.01), and which is no difference among the rest of each IP groups. [Conclusion] Apoptosis has occurred significantly in the forepart of IR which is increasing during IR. And it reachs the summit at 24 hours of reperfusion. IP may decrease the apoptosis of hepatocyte in the forepart of IR, so as to impair the injuries of liver." @default.
- W2351808630 created "2016-06-24" @default.
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- W2351808630 date "2005-01-01" @default.
- W2351808630 modified "2023-09-25" @default.
- W2351808630 title "Relationship of varying apoptosis between ischemic preconditioning and hepatic ischemic reperfusion" @default.
- W2351808630 hasPublicationYear "2005" @default.
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