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- W2351810140 abstract "Objective To observe the effect of Chaigui Wendan Dingzhi Decoction on 5-HT,GABA and Glu in the hippocampus of depression model rats.Methods Rats were randomly divided into six groups.The depression model of rat was established by stimulation of separation and long-term mild unpredicted stress,and the changes of contents of 5-HT,GABA and Glu in the hippocampus of rats were observed.Results Compared with normal control group,the contents of 5-HT and GABA were decreased significantly,the content of Glu was increased significantly in model group.Compared with model group,the contents of 5HT and GABA were increased in various degrees,the content of Glu was decreased in various degrees in fluoxetine group and Chaigui Wendan Dingzhi Decoction groups.Conclusion Chaigui Wendan Dingzhi Decoction has antidepressant effect,and the mechanism is possibly related with increasing the expression level of 5-HT and GABA,decreasing the expression level of Glu in the hippocampus of rats,and regulating the balance of neurotransmitters system." @default.
- W2351810140 created "2016-06-24" @default.
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- W2351810140 date "2010-01-01" @default.
- W2351810140 modified "2023-09-26" @default.
- W2351810140 title "Effect of Chaigui Wendan Dingzhi Decoction on Neurotransmitter in Hippocampus of Depression Model Rats" @default.
- W2351810140 hasPublicationYear "2010" @default.
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