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- W2351844356 abstract "Objective To simulate the rotary cell culture system(RCCS) liver bioreactor model with computational fluid dynamic(CFD) software and to analyze the characteristic of nutrition supply.Methods A numerical analysis of the RWV bioreactor was conducted by incorporating the Eulerian-Eulerian multiphase and oxygen transport equations.The bead type,size and rotating speed were the control variables in the calculations.Results The present results showed that the rotating speed for appropriate suspensions should to be increased as the size of the bead/cell increasing:10 r/min for 200 μm;12 r/min for 300 μm.As the rotating speed and the bead size increasing from 10 r/min(200 μm) to 18 r/min/(600 μm),the mean oxygen concentration in the 80% midzone of the vessel was increased to 85% after 1 hour rotation due to the high convective flow for 18 r/min(600 μm) case as compared to 10 r/min(200 μm) case.Conclusion The present results may serve as criteria to set the operating parameters for a RWV bioreactor,it might provide a design parameter for an advanced suspension bioreactor for 3D engineered cell and tissue culture." @default.
- W2351844356 created "2016-06-24" @default.
- W2351844356 creator A5021239241 @default.
- W2351844356 date "2011-01-01" @default.
- W2351844356 modified "2023-09-24" @default.
- W2351844356 title "Stimulation Analysis of Perfusion Rotary Cell Culture System Bioreactors with Computational Fluid Dynamic Software" @default.
- W2351844356 hasPublicationYear "2011" @default.
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