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- W2351844589 abstract "Objective To discuss the influence of high altitude hypoxia on stress in induced mouse cells.Methods A total of 108 mice(male and female in half) were divided into A,B and C groups,which were subdivided into A1,B1,C1 groups(experimental group) and A2,B2,C2 groups(control group).Group A and C used CR mice,and group B used Wistar rats.Group A1 was quickly accessed to an altitude of 3 820 meters for hypoxia-inducible factor-1α expression analysis.Group B1 was placed in 400 to 420 kPa low-pressure oxygen chamber to observe the effects of different hypoxia exposure time on rat heart mitochondria.Group C was analyzed and compared the plasma levels of vascular endothelial growth factor expression at different altitudes,different oxygen concentrations and different days.Control group was experimented at an altitude of 800 meters.Results The endothelin-1α concentration gradually increased in group A1,and hypoxia-inducible factor-1α of myocardial cells in group A1 was significantly higher than that in group A2.The number of myocardial mitochondria in group B changed with the period in low oxygen condition.The three different concentrations of vascular endothelial growth factor increased with the number of days increased in group C1,which showed a significant difference compared with group C2.Conclusion Low oxygen conditions can promote the expression of hypoxia-inducible factor-1α in myocardial cells.The mice with hypoxia prompt adaptation(acclimatization) process.The regulation of vascular endothelial growth factor is related with the oxygen content,and increases in the expression with the decline in oxygen content." @default.
- W2351844589 created "2016-06-24" @default.
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- W2351844589 date "2010-01-01" @default.
- W2351844589 modified "2023-09-26" @default.
- W2351844589 title "High altitude hypoxia-induced cell stress" @default.
- W2351844589 hasPublicationYear "2010" @default.
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