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- W2351869401 abstract "OBJECTIVE:To investigate the inhibition of sulindac on proliferation of hepatoma HepG2 cells, then to explore the antineoplastic mechanism of sulindac. METHODS: MTT assay was used to examine the effect of sulindac on the proliferation of HepG2 cell and flow cytometry was used for the cell cycle distribution. Apoptosis of HepG2 cells was investigated further by means of transmission electron microscopy and agarose gel electrophoresis. RESULTS: Sulindac inhibited the proliferation of HepG2 cell and the effects were in a time-and-concentration dependent manner, (n=24),r 24 h=0.914, P=0.037; r 48 h=0.921, P=0.041; r 72 h=0.907, P=0.028. Sulinsac also induced apoptosis. After 24 h, the apoptosis rate of control group was (1.5±0.3)%,but it was (8.6±1.3)% in 3×10 -4 treat group (P=0.018), and (27.0±1.7)% in 9×10 -4 treat group (P=0.000). Furthermore, after 48 h, the apoptosis rate increased to 13.2±2.3 in 3×10 -4 treat group (P=0.012), and increased to 37.1±2.9 in 9×10 -4 treat group (P=0.000). Compared with control group, sulinsac increased cell population in the G0/G1 phase in 3×10 -4 treat group (P=0.048) and in 9×10 -4 treat group (P=0.037), after 24 h, it reached (40.4±2.9)% (P=0.040) and (47.2±2.3)% (P=0.032) after 48 h. CONCLUSION: Sulindac inhibits proliferation of HepG2 cells via induction of apoptosis and cell cycle arrest." @default.
- W2351869401 created "2016-06-24" @default.
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- W2351869401 date "2006-01-01" @default.
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- W2351869401 title "Inhibition of sulindac on proliferation of hepatoma HepG_2 cell line" @default.
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