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- W2351870817 abstract "Objective To investigate the angiogenic potentiality of angiopoietin-related protein 2(ARK) in ischemic myocardium of rat in acute ischemic heart model. Methods Male rats were randomized into three groups: ischemic myocardial injection of adenovirus (1×109 pfu)encoding ARP2(GroupⅠ, n = 14), injection of control vector without a transgene (GroupⅡ, n = 14) and injection of PBS(GroupⅢ, n = 14). On the d 28, revascularization function was assessed by MEC(myocardial contrast echocardiography),cardiac function was assessed by echocardiography. After the animals were sacrificed, their hearts were harvested and subjected to histologic studies. Results Myocardial perfusion assessed by MEC and cardiac function assessed by echocardiography in rats 4 weeks after adenovims-encoding ARK administration were significantly improved as compared with those in rats injected with control vector without a transgene or PBS. The endothelial cell count per high power field was increased in GroupⅠversus the control groups. Conclusions Adenovirus encoding ARK induces an enhancement of regional perfusion in ischemic myocardium of rats, thus improving cardiac function. The results indicate for the first time that ARK may act on ischemic myocardium of rats and stimulate angiogenesis, which holds great promise for its future application to revascularization of ischemic myocardium." @default.
- W2351870817 created "2016-06-24" @default.
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- W2351870817 date "2007-01-01" @default.
- W2351870817 modified "2023-09-28" @default.
- W2351870817 title "Stimulation of angiogenesis in rat ischemic myocardium by recombinant human angiopoietin-reiated protein" @default.
- W2351870817 hasPublicationYear "2007" @default.
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