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- W2351874341 abstract "Objective To study the level of mice liver antioxygen and the degree of mice liver pathologiccal damage through intraperitoneal injection of different dose of iron dextran in mice.Method Male and female mice were randomly divided into four groups and were ntraperitoneally injected with different doses of iron dextran every the other day,for six weeks.The levels of MDA,SOD and GSH-PX in the liver and the levels of ALT,AST,AKP and ACP in the blood-serums were measured.Pathohistology analysis of the liver was also performed.Result Comparing with the normal group,the MDA level in the liver was significantly increased(P 0.001),and the levels of SOD and GSH-PX were dramatically decreased(P 0.001).There is no significant difference the levels of AKP and ACP between the normal group and the treated group.The pathohistology examination result showed that iron scatter in the low-dose treated group was more than that in the high-dose group.Conclusion Excess iron cause severe damage of the liver in a dose dependent manner.The mechanism may be the ferrous which release from liver cause lipid peroxidation." @default.
- W2351874341 created "2016-06-24" @default.
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- W2351874341 date "2007-01-01" @default.
- W2351874341 modified "2023-09-23" @default.
- W2351874341 title "Study of the Liver Damage Effect of Different Dosage of Iron Dextran" @default.
- W2351874341 hasPublicationYear "2007" @default.
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