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- W2351880415 abstract "Objective To investigate the association of the C→G single nucleotide polymorphism(SNP) at the 540 position and C→T SNP at the 580 position in the 3′-untranslated region of p16 exon 3 with susceptibility to esophageal squamous cell carcinoma(ESCC) and gastric cardiac adenocarcinoma(GCA) in a population of high incidence region,Ci county and She county of North China.Methods The genotypes of p16 C540G and C580T SNPs were detected by polymerase-chain reaction(PCR)-restriction fragment length polymorphism(RFLP) analysis in 503 cancer patients(265 ESCC and 238 GCA) and 246 healthy controls.Results The genotype and allelotype distribution of the p16 C540G SNP in ESCC and GCA patients was not significantly different from that in healthy controls(all P values were more than 0.05).The genotype and allelotype distribution of the p16 C580T SNP in ESCC and GCA patients was not significantly different from that in healthy controls(all P values were more than 0.05),either.When the two p16 SNPs were combined analyzed,the frequencies of 540C/580C,540C/580T,540G/580C,and 540G/580T haplotype among ESCC(80.8%,9.6%,8.7% and 0.9%),GCA(80.2%,9.2%,9.5% and 1.1%) patients was not significantly different from that in healthy controls(80.1%,10.4%,8.5% and 1.0%)(all P values were above 0.05).Conclusion The p16 C540G and C580T SNPs might not be independent factors to predict the risk of the development of ESCC and GCA in Ci county and She County." @default.
- W2351880415 created "2016-06-24" @default.
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- W2351880415 date "2008-01-01" @default.
- W2351880415 modified "2023-09-24" @default.
- W2351880415 title "Association between p16 Gene C540G and C580T Polymorphisms and Esophageal Squamous Cell Carcinoma and Gastric Cardiac Adenocarcinoma" @default.
- W2351880415 hasPublicationYear "2008" @default.
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