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- W2351891556 abstract "Objective To observe the effect of genistein on learning and memory and oxidative damage in vascular dementia rats. Methods A rat model of vascular dementia was constructed by ligating bilateral common carotid arteries,then reperfusing,and administrating nitroprusside sodium. The rats were divided into four groups: control group,sham-operated group,genistein group (GST group),and estradiol benzoate group (BE2 group). Morris water maze and stand jumping were performed to measure learning and memory in the rats. The contents of superoxide dismutase (SOD),malonaldehyde (MDA),glutathione peroxidase (GSHPx) were detected in the cerebral tissue. Results As compared with the control group,genistein significantly improved the ability of learning and memory,decreased MDA levels,and increased the contents of SOD and GSHPx. Conclusion Genistein can significantly improve the ability of learning and memory in vascular dementia rats by inhibiting oxidative damage and eliminating oxygen free radicals." @default.
- W2351891556 created "2016-06-24" @default.
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- W2351891556 date "2007-01-01" @default.
- W2351891556 modified "2023-09-24" @default.
- W2351891556 title "Effect of genistein on learning and memory and oxidative damage in vascular dementia rats" @default.
- W2351891556 hasPublicationYear "2007" @default.
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