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- W2351910965 abstract "OBJECTIVE To establish a HPLC-ECD method for determining scutellarin in rat plasma and to study pharmacokinetics of scutellarein in rats.METHODS The analytical column was Kromasil C18(4.6 mm×250 mm,5 μm),and the mobile phase consisted of methanol:50 mmol·L-1 phosphate buffer(adjusted by phosphoric acid to pH 2.6):tetrahydrofuran(40∶60∶10).The flow rate was 1.0 mL·min-1.The potential was 100 mV. RESULTS The concentration-time curve of scutellarin (ig scutellarein 20 mg·kg-1) and the main pharmacokinetic parameters were showed in this study. The absolute bioavailability of scutellarein for oral administration was 7.0%.CONCLUSION Scutellarein is easy to absorb orally. Compared with scutellarin,the relative bioavailability is 301.8%." @default.
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- W2351910965 date "2007-01-01" @default.
- W2351910965 modified "2023-09-22" @default.
- W2351910965 title "Study on Pharmacokinetics of Scutellarein in Rats" @default.
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